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Persistent Oral Infections May Increase the Risk of Infectious Complications in Organ Transplant Recipients

Studies involved adult patient undergoing solid organ transplantation. The exposure defined was the presence of oral foci of infection at transplantation or dental treatment before transplantation to eliminate such infections. The comparison was the absence of oral foci at the time of solid organ transplantation.

Robotic-Assisted Simultaneous Bilateral Native Nephrectomy and Living Donor Kidney Transplantation

Simultaneous bilateral nephrectomy and living donor kidney transplantation is commonly recommended for patients with autosomal dominant polycystic kidney disease in end-stage kidney disease. Robotic-assisted surgery provides a minimally invasive option that may decrease perioperative complications and shorten hospital stays.

Tacrolimus Exposure During Pregnancy in Kidney and Liver Transplantation Recipients

This study evaluated tacrolimus concentration-to-dose ratios in kidney or liver transplant recipients before, during and after pregnancy, utilizing linear mixed model analysis.

Double Bridge to Heart Transplantation

Extra Corporeal Membrane Oxygenator is utilized as a “double-bridge” strategy to heart transplantation for severely ill pediatric patients with decompensated heart failure. This study evaluates the outcomes of early versus late crossover in double-bridged patients using the ACTION registry.

Impact of Preoperative Albumin-Bilirubin Grade On Posttransplant Hospitalization in Adult Liver Transplant Recipients

The albumin-bilirubin grade serves as a prognostic tool for hepatocellular carcinoma and is valuable in evaluating liver function and surgical risk. This study aims to analyze the connection between preoperative albumin-bilirubin grade and the duration of hospital and intensive care unit stay following deceased-donor liver transplantation.

Management of Surgical Complications in Pediatric Kidney Transplantation

Graft and patient survival in pediatric kidney transplantation have improved, yet postoperative surgical complications affect up to 15.4% of recipients, threatening graft survival. Due to anatomical differences in children, transplantation requires careful planning. This narrative review outlines the prevalent surgical complications after kidney transplantation in children.

Systemic Issues Plague Life-Saving Organ Transplant Program

Organ transplants provide critical life-saving opportunities for individuals with severe organ diseases or injuries, with around 100,000 individuals on the U.S. waitlist. Ongoing issues affect the timely distribution of organs, raising patient safety and access equity concerns

Optimal Size Matching Leads to a Favorable Outcome for Single-Lobe Living-Donor Lung Transplantation

Living-donor lobar lung transplantation using a single lobar graft is necessary for small pediatric patients receiving oversized grafts or when only one donor is available. This study assesses the post-transplant outcomes associated with single living-donor lobar lung transplantation.

Artificial Intelligence and Predictive Modelling for Precision Dosing of Immunosuppressants in Kidney Transplantation

Optimizing immunosuppressant dosing in kidney transplantation is challenging due to narrow therapeutic ranges and significant inter-patient pharmacokinetic variability.

RSV Vaccination Induces Robust Immune Responses in Solid Organ Transplant Recipients

An observational study published in the American Journal of Transplantation evaluated the cellular and humoral immunogenicity of RSV prefusion F-based vaccines in solid organ transplant recipients and patients with chronic kidney disease.

New Heart Recovery Method May Ease Ethics Concerns With Circulatory Death Donation

A novel way of caring for hearts donated after circulatory death until they can be transplanted showed promise in a case series, with implications for resolving ethical issues around donated after circulatory death procurement.

Leveraging Machine Learning to Predict De Novo Skin Malignancy Following Lung Transplantation

This study focused on predicting posttransplant malignancy risks in lung transplant recipients through machine learning, while also identifying key clinical and immunogenetic predictors.

Public Mistrust Linked to Drop in Deceased Donor Organ Donations and Kidney Transplants

Organ donations from the recently deceased dropped last year for the first time in over a decade, resulting in fewer kidney transplants

Co-Stimulatory Blockade and Infectious Risk in Solid Organ Transplantation

Costimulatory blockade offers a promising alternative to traditional immunosuppression, potentially reducing chronic allograft injury and minimizing drug-related toxicities such as nephrotoxicity, cardiometabolic complications and malignancies.

Expert Guidance On Fecal Microbiota Transplantation in Liver Disease

The gut microbiota is essential for host health and liver function, with fecal microbiota transplantation showing potential as a treatment for chronic liver diseases

New Approaches to Better Regulate the Immune Response After Organ Transplants

The Medical University of Vienna and Therakos, a company specializing in medical technology, have launched a long-term research partnership to further develop extracorporeal photopheresis for solid organ transplantation.

Dual Targeting of B Cell Compartments Using Belatacept and Daratumumab in Highly Sensitized Kidney Transplant Candidates

Highly sensitized kidney transplant candidates encounter challenges in accessing compatible organs because of ongoing anti-HLA antibodies and memory B-cell responses, which are not effectively addressed by existing desensitization therapies.

Incision Techniques in Lung Transplants: A Meta-Analysis

In a groundbreaking study focusing on surgical approaches for bilateral lung transplantation, researchers have conducted a comprehensive meta-analysis to assess the efficacy and outcomes associated with three primary incision techniques: clamshell, median sternotomy and bilateral thoracotomy.

Comparative Outcomes of Transcatheter Arterial Embolization vs Open Surgery for Blunt Abdominal Solid Organ Injury With Concurrent Traumatic Brain Injury

This retrospective observational study analyzed the effectiveness of transcatheter arterial embolization compared to open surgery in patients suffering from blunt abdominal solid organ injuries, specifically to the liver, spleen or kidney, alongside traumatic brain injuries.

Unraveling Cytomegalovirus Drug Resistance in Transplant Patients by Targeting Deep Sequencing

This study utilized next-generation sequencing to detect antiviral resistance mutations in 71 samples from 68 CMV-positive patients posthematopoietic stem cell transplantation or solid organ transplantation.

Characteristics and Treatment Outcomes of Portal Hypertension After Living Donor Liver Transplantation

Portal hypertension following liver transplantation is a significant complication that can lead to graft loss, prompting an investigation into its characteristics and treatment outcomes after living donor liver transplantation.

Freeze-Tolerant Frogs Power Organ Cryopreservation Strategies

During winters, some frogs suspend their physiological processes and freeze themselves solid before bouncing back upon thawing in the spring. Scientists are exploring strategies employed by such animals to extend organ cryopreservation durations. Frogs that freeze themselves solid in the winter and thaw in the spring inspired methods to extend the storage time for transplantable organs.

Impact of High Tacrolimus Exposure on Graft Function and Development of a Prediction Model in Kidney Transplant Recipients

To assess the link between early supratherapeutic tacrolimus exposure in kidney transplant recipients and graft outcomes, and to create a prediction model for outcomes associated with this elevated exposure.

Right Ventricular Functional Improvement After Lung Transplantation and Adjunctive Pulmonary Rehabilitation

Right ventricular dysfunction frequently occurs in advanced lung disease caused by chronic pressure overload and changes in pulmonary vascular mechanics. Lung transplantation alleviates RV afterload, and pulmonary rehabilitation can further improve functional recovery.

Outcomes and Risk of Relapse After Living Donor and Deceased Donor Liver Transplantation for Alcohol-Associated Liver Disease

The study examines the six-month abstinence rule for patients with alcohol-associated liver disease regarding liver transplantation. It questions the reliability of this rule in predicting relapse and contrasts the outcomes of deceased donor versus living donor liver transplantation under revised abstinence criteria.

Comparative Outcomes of Transcatheter Arterial Embolization vs Open Surgery for Blunt Abdominal Solid Organ Injury With Concurrent Traumatic Brain Injury

This retrospective observational study analyzed the effectiveness of transcatheter arterial embolization compared to open surgery in patients suffering from blunt abdominal solid organ injuries, specifically to the liver, spleen or kidney, alongside traumatic brain injuries.

Development of Early Diagnostic Strategies by Targeting CXCR3 Following Heart Transplantation

Early diagnosis and treatment of acute rejection are vital for heart transplantation graft survival. This study identifies CXCR3 as a T cell-specific biomarker using single-cell RNA sequencing and develops a nanoparticle-based fluorescent probe targeting CXCR3 for diagnostic evaluation through in vivo imaging.

All About Multiparametric MRI Evaluation in Biliary Tree Complications After Liver Transplant

Multiparametric magnetic resonance imaging plays a crucial role in evaluating biliary tree complications after liver transplantation, integrating into a multidisciplinary team approach for personalized patient treatment.

Pancreas Transplantation in Type 2 Diabetics is Associated with Lower Rates of Graft Rejection and Graft Loss Compared with Type 1 Diabetics

Diabetes mellitus is the leading cause of chronic kidney disease in the United States, and its prevalence is increasing. Type 2 diabetes (T2D) accounts for the vast majority of diabetics (∼95%), while the majority of pancreas transplants are performed in type 1 diabetics (T1D). We sought to compare the outcomes of pancreas transplantation in T1D vs. T2D to validate increased utilization of pancreas transplants in T2D recipients.

Impact of Donor Age on Graft Failure After Deceased Donor Liver Transplantation by Donor-Recipient Sex Combinations: An Analysis of the UNOS OPTN Database

Sex disparities affect many diseases, including liver conditions and transplant outcomes. Female-to-male liver transplantation (LT) is linked to poorer results, not due to surgical mismatch but likely medical factors such as reduced hepatic estrogen signaling. Prior research shows this disadvantage disappears when the donor is over 40 years old. This study investigates whether the same effect occurs in deceased donor LT using UNOS/OPTN data.

Iron Therapy Can Treat Anaemia in Kidney Transplant Kids

In paediatric kidney transplant recipients with iron deficiency, with or without anaemia, intravenous ferric carboxymaltose therapy was safe and led to significant increases in haemoglobin levels at as early as 1 month after the first dose, with improvements being maintained for up to 12 months.

Natural killer cell-derived granzyme B as a therapeutic target for alleviating graft injury during liver transplantation

Liver transplantation (LT) outcomes can be worsened by graft injury, and natural killer (NK) cell–derived granzyme B (GZMB) may play a key role. Analysis of human LT single-cell RNA-sequencing data and mouse ischemia-reperfusion injury (IRI) models showed NK cells with high GZMB levels were enriched in damaged grafts.

Microbiome-derived reactivation of mycophenolate explains variations in enterohepatic recirculation in kidney transplant recipients

The pivotal role of microbes in drug metabolism is increasingly recognized, as variation in the gut microbiome composition between individuals has been shown to impact systemic drug exposure, efficacy and toxicity. Mycophenolate mofetil (MMF) is a cornerstone in immunosuppressive therapy following solid organ transplantation.

Managing hepatocellular carcinoma recurrence after liver transplantation: emerging role of immune checkpoint inhibitors

Hepatocellular carcinoma (HCC) recurs in 8–20% of liver transplant (LT) cases despite adherence to selection criteria like the Milan criteria, indicating a need for better patient selection and post-transplant care. This review focuses on managing HCC recurrence post-LT, particularly the emerging role of immune checkpoint inhibitors (ICIs). While surgery and locoregional therapies are preferred, systemic treatments—especially tyrosine kinase inhibitors—are often used when disease is widespread.

Development of a Risk Score Predicting Survival After Adult Heart Transplantation in the United States

In the US, donor hearts for transplant are currently allocated to the candidates with the highest risk of death on the waiting list, based on a categorical status-based system. The upcoming continuous distribution provides an opportunity to implement a post-transplant risk score that may help avoid futile transplants.

Genomics in Pancreas–Kidney Transplantation: From Risk Stratification to Personalized Medicine

Pancreas and pancreas–kidney transplants offer life-changing benefits for patients with type 1 diabetes and end-stage kidney disease, including restored insulin production and improved long-term outcomes. However, graft rejection and limited durability remain major challenges. This presentation explores how genetic and immunological factors—beyond traditional HLA matching—impact transplant success.

Use of Impella RP Flex in Post-Heart Transplant Patients with RV Primary Graft Dysfunction

Right ventricular primary graft dysfunction (RV-PGD) is a rare but serious complication following heart transplantation, associated with a high morbidity and mortality. Temporary mechanical circulatory support is indicated when patients fail to respond to pharmacological therapy. This study aimed to evaluate the outcomes of patients with RV-PGD who received RV mechanical support with the Impella RP Flex device at our institution.

Outcomes of Liver Transplantation in Patients With Congenital Heart Disease and Biliary Atresia. A Multicenter Analysis

Congenital heart disease (CHD) frequently coexists with noncardiac malformations. Among which, biliary atresia (BA) occurs in approximately 5%–15% of patients Despite this, outcomes of liver transplantation (LT) in patients with CHD and BA remain unknown.

Combined Body Mass Index and Body Surface Area to Predict Post Kidney Transplant Outcomes in Patients With Obesity

The prevalence of obesity is increasing in both the general and kidney failure populations. Severe obesity (body mass index [BMI] ≥ 40 kg/m2) is considered by many centers to be a barrier to kidney transplantation (KT). Obesity is typically defined using BMI. Body surface area (BSA) is not considered, though may also be important.

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