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Clinical Evolution, Outcomes, and Emerging Preservation Technologies in Pancreas and Islet Transplantation

This review discusses the advancement of transplantation therapies, focusing on the transition from cold storage to dynamic preservation technologies. It explores immunosuppression strategies in islet transplantation, including tolerance induction, costimulation blockade, regulatory T-cell therapies and biomaterial-based local immunoprotection, aimed at improving long-term graft survival while reducing toxicities linked to chronic calcineurin inhibitors.

Association Between Immunologic Risk Factors and Cardiovascular Complications Following Pediatric Kidney Transplantation

Children with chronic kidney disease face an increased risk of early cardiovascular issues. Although adult kidney transplant recipients have established cardiovascular risk factors, recent data on pediatric recipients, specifically concerning post-transplant cardiovascular complications, is lacking

REUP Technique Expands Access to Pediatric Heart Transplants

A groundbreaking donor heart recovery technique developed at Vanderbilt Health has been successfully adapted for children by pediatric heart transplant surgeons at Monroe Carell Jr. Children's Hospital at Vanderbilt, potentially expanding access to lifesaving heart transplants for children.

Why Older Lung Transplant Patients Struggle to Protect Their Bones at Home

New research from China suggests that this stacking effect may be quietly undermining the bone health of older lung transplant recipients after they leave the hospital, and the findings offer a rare, detailed look at why home-based osteoporosis care so often falls short in this vulnerable population.

4 in 10 Liver Transplant Recipients Are Not Vaccinated Against Hepatitis B

Only 60% of liver transplant recipients are vaccinated against hepatitis B virus, putting them at risk for serious complications, according to a study published in Clinical Infectious Diseases. Older male patients with less than a high school education and alcohol-associated liver disease were the least likely to be vaccinated.

Acute Kidney Injury Affects 31% After Paediatric Liver Transplantation

Acute kidney injury affected nearly one-third of paediatric liver transplant recipients, with a meta-analysis identifying multiple perioperative and patient-related factors that may influence postoperative risk. The findings highlighted the importance of identifying patients at increased risk and strengthening management throughout the perioperative period.

Hourglass Optimization in Pancreas Transplantation

Pancreas transplantation offers sustainable metabolic control for patients with insulin-dependent diabetes but carries risks of early technical failure, primarily due to ischemia-reperfusion injury. This systematic review explores the impact of timing factors in donor management, procurement, and implantation on early complications and pancreas graft survival, which remains inadequately understood.

Outcomes Steady as Hearts Donated After Circulatory Death Rise in the US

Heart transplants obtained through donation after circulatory death are on the rise in the U.S., with stable early outcomes through this rapid expansion, data from the United Network for Organ Sharing registry suggest.

Chronic Beryllium Disease Mimicking Hypersensitivity Pneumonitis Leading to Lung Transplantation

Chronic beryllium disease is a granulomatous lung condition resulting from immune sensitization to beryllium, resembling other interstitial lung diseases such as hypersensitivity pneumonitis and sarcoidosis.

Patients With Developmental Disabilities Still Face Kidney Transplant Disparities Despite State Laws

State laws to combat disability-based discrimination in the organ transplant process aren't working, according to new research from The Ohio State University College of Medicine. The study, published in JAMA Internal Medicine, examines national policies designed to help all patients have a fair chance to receive an organ transplant.

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