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Implantable Mini-Livers Could Transform Liver Disease Treatment

In patients developing end-stage liver disease, the damage has become too severe for the liver's normally extraordinary regenerative capacity to repair or compensate for it. A research team has developed implantable mini-livers that grow inside the body, offering a solution for liver disease treatment.

Intravenous Immunoglobulin In Solid-Organ Transplantation

The survival of kidney and lung allografts continues to be threatened by sensitization, donor-specific antibody formation and antibody-mediated rejection. Intravenous immunoglobulin has been incorporated into three major clinical contexts central to transplant medicine: desensitization before transplantation, treatment of antibody-mediated rejection, and replacement or adjunctive therapy for post-transplant hypogammaglobulinemia or increased risk for infection.

Donor Derived Cell Free DNA May Aid Monitoring of Kidney Transplant Recipients

Tests measuring donor-derived cell-free DNA are revolutionizing the monitoring of kidney transplant recipients, enabling earlier detection of graft injury and potentially decreasing the need for invasive graft biopsies.

Pediatric Heart Transplant Demand Rises Amid Severe Donor Shortage

Advances in pediatric heart care are helping more children survive long enough to receive a transplant-but a critical shortage of donor hearts means too many are still dying while they wait, experts warned today at the International Society for Heart and Lung Transplantation 46th Annual Meeting and Scientific Sessions.

Cardiogenic Shock in Heart Transplant Recipients

This study evaluated the prognosis of heart transplant recipients experiencing graft failure-related cardiogenic shock, identified predictors of one-year event-free survival and compared their outcomes to patients with other cardiogenic shock etiologies.

Immunosuppressive Therapies in Kidney Transplant Recipients

For more than two decades, the field of kidney transplantation has seen little advancement in immunosuppressive therapies. While current treatments are effective, there still exists a patient population with unmet needs who have a poor tolerance to these drugs. This survey was driven by a need for awareness of this challenge.

The Prevalence and Consequences of Supra-Normal Estimated Glomerular Filtration Rate in Pediatric Solid Organ Transplants

In adult kidney transplant recipients, renal hyperfiltration correlates with a greater risk of graft loss. Data regarding pediatric solid organ transplant recipients is limited.

Hepatitis E Risk Higher in Liver Transplant Patients

Hepatitis E virus infection affects a small but clinically significant proportion of solid organ transplant recipients, with recent long-term data highlighting risks of chronic hepatitis, treatment outcomes, and extrahepatic manifestations. A single-centre retrospective analysis of 6,452 transplant recipients followed from 2001 to 2024 found that 228 patients were diagnosed with HEV infection, with liver transplant recipients showing a higher incidence than other transplant groups.

Pancreas Transplantation in the Modern Era

Over the past decade, there has been a global decline in pancreas transplant volume. Factors like procurement extraction time, crucial for organ recovery, should be understood to boost confidence in organ acceptance and enhance utilization

Impact of Prior Kidney Transplantation on Symptom Burden and Health-Related Quality of Life in Incident Dialysis Patients

Data on symptom burden and health-related quality of life in patients with kidney graft failure returning to dialysis are scarce. This study assessed these parameters in the first year of dialysis for prior-transplant patients and compared them to transplant-naive incident dialysis patients

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