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How 72-Hour Kidney Storage Could Transform Transplants

Donated organs deteriorate quickly, leaving surgeons only hours to act. Researchers developed a pressure-controlled system that keeps kidneys below freezing without forming damaging ice.

Genetic Testing After Heart Transplantation Uncovers Heritable Disease and Drives Family Screening

Genetic testing is pivotal in ambulatory cardiomyopathy, yet its role for heart transplant recipients is not well-defined. This study investigates the clinical utility of genetic testing for adult heart transplant patients with cardiomyopathy, emphasizing etiologic reclassification, family cascade screening, and the genetic factors linked to end-stage disease.

Living Donor Liver Transplantation as Salvage Therapy for Steroid-Refractory Chronic Hepatic GVHD Following Allogeneic Hematopoietic Stem Cell Transplantation

Steroid-refractory hepatic graft-versus-host disease has significant mortality risks and limited treatment options. Liver transplantation post-hematopoietic stem cell transplantation is uncommon, especially in pediatric cases due to intricate alloimmunity. This report highlights a successful living donor liver transplantation from a parent to a pediatric patient.

Cancer Immunotherapy After Solid Organ Transplantation

Few clinical scenarios in modern oncology are as challenging or as thought provoking as treating cancer in patients who have previously undergone solid organ transplantation. Immune checkpoint inhibitors have fundamentally transformed cancer treatment, producing durable responses and long term survival in diseases once considered uniformly fatal.

COVID-19 Study Supports Antiviral Use in Kidney Transplant Recipients

In a target trial emulation, starting remdesivir soon after a COVID-19 diagnosis was associated with a 47% lower risk of graft failure or death at one year.

Single-Shot Intrathecal Morphine in Bilateral Lung Transplantation

Bilateral lung transplantation through clamshell thoracotomy results in significant postoperative pain. At the researchers' center, thoracic epidural analgesia is the standard practice, although it involves risks related to hemodynamics, catheter-related issues and anticoagulation during the early post-transplant phase.

EHR-Derived Marker May Help Curb Risk for Liver Transplant Rejection

A remote behavioral intervention guided by the Medication Level Variability Index, an electronic health record-derived marker based on routinely collected immunosuppressant blood levels, showed potential to lower the risk for rejection among adolescent and young adult recipients of liver transplant, although the results were not statistically significant.

Xenotransplantation Enters a New Era

As the waitlist for donor organs grows, surgeon Leonardo Riella sees animal-to-human kidney transplants getting closer to the clinic.

More Than a New Heart: Psychological Adjustment and Quality of Life Following Heart Transplantation

This study employs mixed methods to explore changes in depression, anxiety and health-related quality of life among heart transplantation recipients from hospital discharge to three months, incorporating qualitative insights.

Report Highlights Rising Concern Over Donor-Derived KSHV in Transplant Recipients

Public investment in liver transplants not only saves lives and substantially improves patients' survival and quality of life but also generates a positive long-term social and economic return. That is the finding of a pioneering study led by researchers from Pompeu Fabra University, the National Transplant Organization and Vall d'Hebron University Hospital.

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