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Pancreas Transplantation in Type 2 Diabetics is Associated with Lower Rates of Graft Rejection and Graft Loss Compared with Type 1 Diabetics

Diabetes mellitus is the leading cause of chronic kidney disease in the United States, and its prevalence is increasing. Type 2 diabetes (T2D) accounts for the vast majority of diabetics (∼95%), while the majority of pancreas transplants are performed in type 1 diabetics (T1D). We sought to compare the outcomes of pancreas transplantation in T1D vs. T2D to validate increased utilization of pancreas transplants in T2D recipients.

Impact of Donor Age on Graft Failure After Deceased Donor Liver Transplantation by Donor-Recipient Sex Combinations: An Analysis of the UNOS OPTN Database

Sex disparities affect many diseases, including liver conditions and transplant outcomes. Female-to-male liver transplantation (LT) is linked to poorer results, not due to surgical mismatch but likely medical factors such as reduced hepatic estrogen signaling. Prior research shows this disadvantage disappears when the donor is over 40 years old. This study investigates whether the same effect occurs in deceased donor LT using UNOS/OPTN data.

Iron Therapy Can Treat Anaemia in Kidney Transplant Kids

In paediatric kidney transplant recipients with iron deficiency, with or without anaemia, intravenous ferric carboxymaltose therapy was safe and led to significant increases in haemoglobin levels at as early as 1 month after the first dose, with improvements being maintained for up to 12 months.

Natural killer cell-derived granzyme B as a therapeutic target for alleviating graft injury during liver transplantation

Liver transplantation (LT) outcomes can be worsened by graft injury, and natural killer (NK) cell–derived granzyme B (GZMB) may play a key role. Analysis of human LT single-cell RNA-sequencing data and mouse ischemia-reperfusion injury (IRI) models showed NK cells with high GZMB levels were enriched in damaged grafts.

Microbiome-derived reactivation of mycophenolate explains variations in enterohepatic recirculation in kidney transplant recipients

The pivotal role of microbes in drug metabolism is increasingly recognized, as variation in the gut microbiome composition between individuals has been shown to impact systemic drug exposure, efficacy and toxicity. Mycophenolate mofetil (MMF) is a cornerstone in immunosuppressive therapy following solid organ transplantation.

Managing hepatocellular carcinoma recurrence after liver transplantation: emerging role of immune checkpoint inhibitors

Hepatocellular carcinoma (HCC) recurs in 8–20% of liver transplant (LT) cases despite adherence to selection criteria like the Milan criteria, indicating a need for better patient selection and post-transplant care. This review focuses on managing HCC recurrence post-LT, particularly the emerging role of immune checkpoint inhibitors (ICIs). While surgery and locoregional therapies are preferred, systemic treatments—especially tyrosine kinase inhibitors—are often used when disease is widespread.

Development of a Risk Score Predicting Survival After Adult Heart Transplantation in the United States

In the US, donor hearts for transplant are currently allocated to the candidates with the highest risk of death on the waiting list, based on a categorical status-based system. The upcoming continuous distribution provides an opportunity to implement a post-transplant risk score that may help avoid futile transplants.

Genomics in Pancreas–Kidney Transplantation: From Risk Stratification to Personalized Medicine

Pancreas and pancreas–kidney transplants offer life-changing benefits for patients with type 1 diabetes and end-stage kidney disease, including restored insulin production and improved long-term outcomes. However, graft rejection and limited durability remain major challenges. This presentation explores how genetic and immunological factors—beyond traditional HLA matching—impact transplant success.

Use of Impella RP Flex in Post-Heart Transplant Patients with RV Primary Graft Dysfunction

Right ventricular primary graft dysfunction (RV-PGD) is a rare but serious complication following heart transplantation, associated with a high morbidity and mortality. Temporary mechanical circulatory support is indicated when patients fail to respond to pharmacological therapy. This study aimed to evaluate the outcomes of patients with RV-PGD who received RV mechanical support with the Impella RP Flex device at our institution.

Outcomes of Liver Transplantation in Patients With Congenital Heart Disease and Biliary Atresia. A Multicenter Analysis

Congenital heart disease (CHD) frequently coexists with noncardiac malformations. Among which, biliary atresia (BA) occurs in approximately 5%–15% of patients Despite this, outcomes of liver transplantation (LT) in patients with CHD and BA remain unknown.

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